MRGX2 is a Gq- and Gi-coupled GPCR that binds to several peptides, including the neuropeptide cortistatin-14 and the proadrenomedullin N-terminal peptide (PAMP). It is probably involved in the function of nociceptive neurons and regulation of nociceptor function and/or development, including the sensation or modulation of pain. Dorsal root ganglia and adrenal chromaffin cells express MRGX2, and binding of these ligands to MRGX2 is thought to play a role in nociception and catecholamine release from the adrenal glands.