CH27 Mouse B Cell Lymphoma Cell Line is one of the CH series of mouse B-cell lymphomas that arise from the spleen cells of B10.H-2a-H-4b p/Wts (2a4b) mice, either spontaneously or after transplantation of the spleen cells to syngeneic or F1 hybrid recipients . CH27 cells express surface IgM and Ia antigens along with Ly-1 (CD5) and Ig which bind sheep (SRBC) and chicken erythrocytes and bromelain-treated mouse erythrocytes . The hapten recognized by SRBC-binding CH lymphomas is a phospholipid, either phosphatidylchone or sphingomyelin . Phospholipids are a common component of cell membranes and thus cells expressing immunoglobulin with specificity for SRBC can also be found in the spleens of normal mice . This suggests that CH lymphomas represent neoplastic analogues of Ly-1+ normal B-cells .
Synonyms: CH27 [Mouse lymphoma]
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