Cefoperazone sodium salt is a broad spectrum third generation cephalosporin antibiotic that has similar antimicrobial activity to ceftazidime. It is active against Pseudomonoas aeruginosa and it has enhanced activity against Enterobacteriaceae and Bacteroides sp. in the presence of the beta-lactamase inhibitor sulbactam. Compared to cefotaxime, cefoperazone has greater susceptibility to hydrolysis by some beta-lactamases.
Cefoperazone sodium salt is used to study drug-protein binding, expression and inhibition of penicillin-binding proteins (PBPs) during cell wall synthesis.
Cefoperazone exerts its bactericidal effect by inhibiting the bacterial cell wall synthesis. Cefoperazone has a dual excretory pattern, primarily via the biliary system and secondarily via the kidney.
Grade: USP
Assay: 870 - 1015 µg/mg
Key Applications: Interferes with cell wall synthesis
Product Type: Biochemicals
Biochemical Category: Antibiotics
Chemical Class: Biochemicals
Presentation: White powder
Format: Powder
pH: (1 in 4) 4.5 - 6.5
Water Content: ≤5.0%
Solubility: Soluble in water (50 mg/mL - clear, faint yellow solution).
Storage & Handling: +4°C