Synonyms: 4-(4-Fluoro-2-methylindol-5-yloxy)-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline; 4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(1-pyrrolidinyl)propoxy]quinazoline; 4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline; AZD 2171; AZD2171
Molecular Formula: C25H27FN4O3
Molecular Weight: 450.51
Linear Structural Formula: C25H27FN4O3
MDL Number: MFCD09954115
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Cediranib (AZD2171) is an orally active anticancer agent and a highly potent ATP-competitive receptor tyrosine kinase (RTK) inhibitor against VEGFR (IC50 = 5 nM/Flt-1 (VEGFR1),<1 nm dr (vegfr2), <="3" nm lt-4 (vegfr3), c-kit (ic50="2" nm), pdgfr1 (ic50="5/36" nm), and fgfr1 (ic50="26" nm). cediranib exhibits reduced activity against csf-1r, src, abl (ic50="110," 130, 260 nm, respectively) and little or no potency toward flt-3, egfr, erbb2 (her-2 eu), cdk2 , aurora a , and mek.<>