Synonyms: Ceapin-7; N-(1-{[2,4-bis(Trifluoromethyl)phenyl]methyl}-1H-pyrazol-4-yl)-5-(furan-2-yl)-1,2-oxazole-3-carboxamide
Molecular Formula: C20H12F6N4O3
Molecular Weight: 470.32
Linear Structural Formula: C20H12F6N4O3
MDL Number: MFCD31567506
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: The pyrazole amide Ceapin-A7 is a potent and highly specific ER stress-induced ATF6alpha signaling blocker (IC50 = 590 nM by HEK293T-based ERSE-luciferase reporter assay, ATF6alpha target transcripts GRP78/ERO1B/HERPUD1 induction IC50 = 459/522/614 nM in U2OS cells; ER stress by 100 nM Thapsigargin) that does not affect IRE1 or PERK branches of the unfolded protein response (UPR), nor proteolytic processing of its close homolog ATF6beta or SREBP. Ceapin-A7 sensitizes U2-OS cells to ER stress-induced death (thapsigargin EC50 = 4.5/7.1 nM with/without 6 muM Ceapin-A7) without impacting the viability of unstressed cells.