Protein tyrosine phosphatase. Catalytic domain, (584-1256) (Gene bank accession number NM_080922) with N-terminal His tag, MW = 75 kDa, expressed in a Baculovirus Sf9 expression system.
Synonyms: CD45R; Leukocyte common antigen (LCA); PTPRC; Protein tyrosine phosphatase, receptor type, C; T200 leukocyte common antigen
Purity: >=90% (SDS-PAGE)
Storage: -70C
Application: Useful for the study of enzyme kinetics, regulation, and to dephosphorylate target substrates.
Biochem Physiol Actions: Protein tyrosine phosphatase, receptor type C (PTPRC) or leucocyte common antigen CD45 acts as a protein tyrosine phosphatase in leucocyte signaling. It has a role in flow cytometric diagnostics in leukemia. By dephosphorylation of Src kinases, the protein acts as a regulator of antigen receptor signaling in T and B cells. As a negative regulator of Janus kinases, CD45 inhibits cytokine receptor signaling.