Synonyms: 9H-Carbazole-9-ethanamine, N,N-diethyl-3,6-dinitro- trifluoroacetate; Curaxin CBLC000 trifluoroacetate; N,N-Diethyl-3,6-dinitro-9H-carbazole-9-ethanamine trifluoroacetate
Molecular Formula: C18H20N4O4 · C2HF3O2
Molecular Weight: 470.4
Linear Structural Formula: C18H20N4O4 · C2HF3O2
Purity: >=95% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: CBLC000 is a potent inhibitor of FACT (facilitates chromatin transcription) complex that activates p53 and suppresses NF-kB without genotoxicity. CBLC000 induces chromatin trapping of FACT both in vitro and in vivo. CBLC000 exhibits brad anticancer activity. CBLC000 analog clinical candidate CBL0137 decreases self-renewal of GBM stem cells (GSC).