A potent, selective, reversible, competitive, non-peptide inhibitor of cathepsin G [IC50 = 53 nM and Ki = 63 nM]. Weakly inhibits chymotrypsin (Ki = 1.5 µM) and poorly inhibits thrombin, factor Xa, factor IXa, plasmin, trypsin, tryptase, proteinase 3, and human leukocyte elastase (IC50 >100 µM).
Synonyms: Cathepsin G Inhibitor I - CAS 429676-93-7 - Calbiochem
Molecular Formula: C36H33N2O6P
Molecular Weight: 620.63
Linear Structural Formula: C36H33N2O6P
Purity: >=98% (HPLC)
Biochem Physiol Actions: Target Ki: 63 nM for cathepsin G
Legal Information: CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes: Greco, M.N., et al. 2002. J. Am. Chem. Soc.124, 3810.