This gene is mapped to human chromosome 11p15.5.
Synonyms: CLN10; CPSD; CTSD
Purity: >=95% (SDS-PAGE)
Storage: -20C
Biochem Physiol Actions: Cathepsin D (CatD) takes part in the intracellular degradation of advanced glycation end (AGE) products. AGE deposition is predominant in photoaged skin. Thus, CatD might be useful in antiphotoaging therapy. Elevated circulating CatD is observed in type 2 diabetes and can be considered as an important biomarker for type 2 diabetes dependent cardiac dysfunction. Increased CatD, is observed in non-alcoholic steatohepatitis.