A cytolytic toxin that causes depolarization of skeletal muscle fibers in vitro. Stimulates Ca2+ transport and ATP hydrolysis by the sarcolemmal Ca2+/Mg2+-ATPase. Its action is strongly potentiated by phospholipase A2. Inhibits protein kinase C (IC50 = 1.8 µM).
Synonyms: Cardiotoxin, Naja pallida
Purity: >=95% (HPLC)
Storage: 2-8C
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Other Notes: Jang, J.Y., et al. 1997. Biochemistry 36, 4635.Huang, J.L., and Trumble, W.R. 1991. Toxicon29, 31.Raynor, R.L., et al. 1991. J. Biol. Chem.266, 2753.Grognet, J.M., et al. 1986. Mol. Immunol.23, 132.