An unsubstituted carbamoyl ester that acts as an agonist for nicotinic and muscarinic acetylcholine receptors. Known to increase cytosolic Ca2+ and InsP3 and decrease cAMP levels. Resistant to the action of acetylcholine esterase (AChE) and non-specific cholinesterases. Inhibits apoptotic death of cultured granule neurons.
Synonyms: Carbachol - CAS 51-83-2 - Calbiochem; Carbamoylcholine Chloride
Molecular Formula: C6H15ClN2O2
Molecular Weight: 182.65
Linear Structural Formula: C6H15ClN2O2
MDL Number: MFCD00012011
Purity: >=99% (titration)
Biochem Physiol Actions: Primary TargetAgonist for nicotinic and muscarinic acetylcholine receptors
Legal Information: CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes: Jence, M., et al. 1995. J. Neurochem. 64, 1605.Yan, G.M., et al. 1995. Mol. Pharmacol. 47, 248.Mangels, L.A., and Gnegy, M.E. 1992. J. Biol. Chem.267, 5847.Watanabe, A.M., et al. 1992. In Basic and Clinical Pharmacology, Fifth Edition Katzung, B.G. ed.) Appleton and Lange, Norwalk, CT, p. 82.Howe, P.H., et al. 1986. J. Pharmacol. Exp. Ther.239, 574.