Synonym: 8-Methyl-N-vanillyl-trans-6-nonenamide
CAS Number: 404-86-4
Linear Formula: (CH3)2CHCH=CH(CH2)4CONHCH2C6H3-4-(OH)-3-(OCH3)
Molecular Weight: 305.41
Beilstein Registry Number: 2816484
EC Number: 206-969-8
MDL Number: MFCD00017259
PubChem Substance ID: 24896598
Biochem/physiol Actions
Prototype vanilloid receptor agonist. Neurotoxin; activates sensory neurons that give rise to unmyelinated C-fibers, many of which contain substance P. Topical application desensitizes the sensory nerve endings giving a paradoxical antinociceptive effect; systemic administration can be neurotoxic to capsaicin-sensitive cells, especially in newborn animals. Active component of chili peppers.
Solubility: H2O: insoluble; ethanol: soluble
Storage Temp.: 2-8°C
Gene Information: human ... CYP1A2(1544), TRPV1(7442); rat ... Trpv1(83810), Trpv4(66026)