Synonym: CaM, Phosphodiesterase 3′:5′-cyclic nucleotide activator
CAS Number: 77107-46-1
MDL number: MFCD00131869
Calmodulin from bovine testes has been shown to activate a plasma membrane (Ca2+Mg2+)-ATPase in porcine aortic endothelial cells.
Biochem/physiol Actions
Ca2+ binding protein that is required for activation of cyclic nucleotide-dependent phosphodiesterase. It is also a cofactor/activator of nitric oxide synthase, calcineurin, and many kinases including ATPase, myosin light chain kinase, and CAM kinase I, II, and III. It mediates ryanodine receptor activation by cyclic ADP ribose and is involved in intracellular Ca2+ homeostasis.