Synonyms: 3-(5-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione; E3 ligase ligand; Ligand for PROTAC(R) research
Molecular Formula: C13H13N3O3
Molecular Weight: 259.26
Linear Structural Formula: C13H13N3O3
MDL Number: MFCD31692701
Purity: >=95%
Storage: 2-8C
Application: C5 Lenalidomide is a derivative of the Cereblon (CRBN)-binding ligand lenalidomide, which possesses an amine at the C4 position. C5 Lenalidomide can be used to bind the CRBN E3 ubiquitin ligase in targeted protein degradation research or in the synthesis of protein degraders with a C5 exit vector. Learn more about proteolysis-targeting chimeras (PROTACs) and the building blocks to design them in our Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPortal: Building PROTAC(R) Degraders for Targeted Protein DegradationAmino-substituted thalidomide analogs: potent inhibitors of TNF-alpha productionTargeted Protein Degradation by Small Molecules