Synonyms: C 176; C176; N-(4-Iodophenyl)-5-nitro-2-furancarboxamide; N-(4-Iodophenyl)-5-nitrofuran-2-carboxamide; Sting inhibitor 1; Sting inhibitor C-176
Molecular Formula: C11H7IN2O4
Molecular Weight: 358.09
Linear Structural Formula: C11H7IN2O4
MDL Number: MFCD00784208
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: C-176 is a potent and selective inhibitor against murine, but not human, stimulator of interferon genes (STING) via covalent modifiation of mSTING Cys91. C-176 inhibits STING-mediated IFNbeta reporter activity (IC50 <50 nm) without affecting rig-i, and blocks (1 mum) downstream tbk1 phosphorylation induction by sting agonist cma (1.4 h) in msting-expressing hek293t cells. c-176 markedly reduces cma-induced serum il-6 & type i ifns in mice (by>=85% 4 h post CMA; 750 nmol C-176/mouse i.p. 1 or 4 h prior to 224 mg/kg CMA) and significantly ameliorates the autoinflammatory severity in Trex1-/- mice.