Synonyms: Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys (Asp-Lys), acetate salt; Acetyl-[Nle4, Asp5, D-Phe7, Lys10]-cyclo-alpha-melanocyte; PT 141 acetate; PT-141 acetate; PT141 acetate
Molecular Formula: C50H68N14O10 · xC2H4O2
Linear Structural Formula: C50H68N14O10 · xC2H4O2
Purity: >=98% (HPLC)
Storage: -20C
Biochem Physiol Actions: Bremelanotide (PT-141) is a brain-penetrant, alpha-melanocyte-stimulating hormone (α-MSH)-derived cyclic heptapeptide agonist toward melanocortin receptors, including MC1R, MC3R and MC4R (affinty = 10 nM by competitive binding against 0.2 nM NDP-α-MSH using human MC4R-expressing HEK-293). Bremelanotide induces cAMP accumulation in hMC4R-expressing HEK-293 cells and exhibits in vivo sexual arousal efficacy among both male (50 μg/kg intranasally or 50-500 pg/kg via lateral ventricle injection) and female rats (100-200 μg/kg sc or 800 μg/kg via lateral ventricle injection) by activating neurons in brain regions responsible for sexual function.