Bone morphogenetic protein 4 (BMP4) is a member of the transforming growth factor-ß (TGF-ß) superfamily. It is a glycoprotein with cysteine knot and exists as homodimer corresponding to a molecular mass of 26 kDa. BMP4 is mapped to human chromosome 14q22.2. BMP4 is expressed in embryonic and adult tissues. It is synthesized in the endoplasmic reticulum and in Golgi, it undergoes posttranslational modifications.
Synonyms: BMP-4
MDL Number: MFCD01867024
Purity: >95% (SDS-PAGE)
Storage: -20C
Application: Bone morphogenetic protein 4 human has been used to induce cardiac myogenic differentiation in bone marrow-derived mesenchymal stem cells (MSC).
Biochem Physiol Actions: Bone morphogenetic protein 4 (BMP4) is essential for auditory neurogenesis. It also mediates the mesenchyme formation and acts as a key differentiation factor for hematopoietic and nerve cells. The BMP4 based signaling is upregulated in both. oligodendrocyte progenitor cells (OPCs) neural precursor cells (NPCs). Cellular responses to BMP-4 are mediated by the formation of heterooligomeric complexes of type I and type II serine/threonine kinase receptors, which play significant roles in BMP binding and signaling. Frameshift mutations in the BMP4 is implicated in the developmental anomalies especially with optic vesicle and digits. BMP4 mutations have also been associated with orbicularis oris muscle (OOM) and lip morphological defects.
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