Synonyms: 2,2-Dimethyl-4-oxo-3,8,11,14,17-pentaoxa-5-azanonadecan-19-oic acid; Boc-NH-PEG4-CH2COOH
Molecular Formula: C15H29NO8
Molecular Weight: 351.39
Linear Structural Formula: C15H29NO8
Density: 1.1395 g/mL
Refractive Index: n/D 1.4641
Storage: -20C
Application: This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC(R) molecules) for targeted protein degradation
Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes: A Hexylchloride-Based Catch-and-Release System for Chemical Proteomic ApplicationsA Biocompatible Condensation Reaction for the Labeling of Terminal Cysteine Residues on Proteins