Synonyms: ((S)-2-((S)-2-((tert-Butoxycarbonyl)amino)propanamido)-2-cyclohexylacetyl)-L-prolyl-L-phenylalanine; AVP ligand; IAP E3 ligase lead for protein degrader research; SNIPER building block
Molecular Formula: C30H44N4O7
Molecular Weight: 572.69
Linear Structural Formula: C30H44N4O7
Purity: >=95%
Storage: 2-8C
Application: BocA1V2PF1 is an in silico-derived inhibitor of apoptosis protein (IAP)-recruiting ligand for targeted protein degradation and SNIPER (specific and non-genetic IAP-dependent protein erasers) development, launched in partnership with ComInnex. Learn more about the novel IAP ligands generated through virtual screening of AVP mimetics in our Technology Spotlight. A C-terminal variant of BocA1V2PF1 is also available as A1V2PF1-NHEt (917222).BocA1V2PF1 conjugates are also available for degrader synthesis. Browse our full synthesis offering here for streamlining SNIPER and PROTAC(R) degrader libraries: Degrader Building Blocks917966 BocA1V2PF1-NHC6-NH2916706 BocA1V2PF1-NHC10-NH2916951 BocA1V2PF1-NHPEG1-NH2917214 BocA1V2PF1-NHPEG3-NH2Technology Spotlight: Degrader Building Blocks with Inhibitor of Apoptosis Protein (IAP) In Silico-Derived Ligands
Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes: In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)SNIPERs-Hijacking IAP activity to induce protein degradationE3 Ligase Ligands for PROTACs: How They Were Found and How to Discover New Ones