Synonyms: 2-((1-Benzyl-1H-indazol-3-yl)methoxy)-2-methylpropanoic acid; 2-Methyl-2-[[1-(phenylmethyl)-1H-indazol-3-yl]methoxy]propanoic acid; AF 2838; AF2838
Molecular Formula: C19H20N2O3
Molecular Weight: 324.37
Linear Structural Formula: C19H20N2O3
MDL Number: MFCD00866723
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Bindarit is an indazolic derivative with anti-inflammatory efficacy in vitro (150-300 muM) and in animal disease models in vivo (100 mg/kg ip, 50 mg/kg po, or 0.5% in chow; rats & mice). Bindarit selectively inhibits LPS-induced CCL2/MCP-1, CCL7/MCP-3, CCL8/MCP-2 chemokines over CCL3/MIP-1alpha and IL-8/CXCL8 in human monocytes, while blocking CCL2, but not CCL7 or CCL8, induction in HUVECs, and preventing LPS-induced CCL2 & IL-12beta/p40 by inhibiting NFkappaB activation in murine macrophages (BMDM & Raw 264.7). Bindarit is also reported to exhibit non-competitive inhibiory potency against human monocarboxylate transporter MCT4 (Ki = 30.2 muM) over MCT1 (<40 % inhibition at 500 mum).<>