Synonyms: MK-4448; MLN1021; N-(5-Chloro-2-pyridinyl)-2-[[4-[(dimethylamino)iminomethyl]benzoyl]amino]-5-methoxybenzamide; N-(5-Chloropyridin-2-yl)-2-(4-(N,N-dimethylcarbamimidoyl)benzamido)-5-methoxybenzamide; PRT-054021; PRT054021
Molecular Formula: C23H22ClN5O3
Molecular Weight: 451.91
Linear Structural Formula: C23H22ClN5O3
MDL Number: MFCD16038040
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: Betrixaban is an orally active, active site-targeting, highly potent and selective factor Xa (fXa) inhibitor (IC50 = 1.5 nM; Ki = 117 pM) with much reduced plasma kallikrein inhibitory activity (IC50 = 6.3 muM) and little potency against thrombin, trypsin, t-PA, aPC or plasmin inhibition (IC50 >10 muM). Betrixaban exhibits good pharmacokinetic properties and anticoagulant efficacy against various thromboembolism (VTE) events in vivo.