Betamethasone is a synthetic corticosteroid.{64715} In vivo, betamethasone (5 mg/kg) reduces bronchoalveolar lavage fluid (BALF) matrix metalloproteinase-2 (MMP-2) and MMP-9 activities, TNF-a levels, and neutrophil number in a mouse model of LPS-induced lung injury. Prenatal administration of betamethasone (0.1 mg/kg) improves neonatal lung function but decreases hippocampal and corpus callosum neuron density and induces motor function deficits in a rabbit model of late preterm birth.{64716} It also extends gestational length in a rat model of preterm labor induced by high mobility group protein B1 (HMGB1).{64717} Formulations containing betamethasone have been used in the treatment of inflammatory skin conditions and prenatally to promote fetal lung maturation.
Technical Information
Formal Name
4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-benzamide
CAS Number
864731-61-3
Synonyms
A-1443
AH 252723
Molecular Formula
C22H17Cl2F6N3O3
Formula Weight
556.3
Purity
98%
Formulation
(Request formulation change)
A crystalline solid
Solubility
(Learn about Variance in Solubility)
DMF: 30 mg/ml
DMSO: 30 mg/ml
DMSO:PBS (pH 7.2) (1:2): 0.25 mg/ml
λmax
265 nm
SMILES
CC1=CC(C2=NOC(C3=CC(Cl)=CC(Cl)=C3)(C(F)(F)F)C2)=CC=C1C(NCC(NCC(F)(F)F)=O)=O
InChi Code
InChI=1S/C22H17Cl2F6N3O3/c1-11-4-12(2-3-16(11)19(35)31-9-18(34)32-10-21(25,26)27)17-8-20(36-33-17,22(28,29)30)13-5-14(23)7-15(24)6-13/h2-7H,8-10H2,1H3,(H,31,35)(H,32,34)
InChi Key
MLBZKOGAMRTSKP-UHFFFAOYSA-N
Shipping & Storage Information
Storage -20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
Shelf life: 4 years