Synonyms: 2',3',4',5',6'-Pentafluoro-3-({(E)-[(1R,2S)-2-{[(2',3',4',5',6'-pentafluoro-2-hydroxy[1,1'-biphenyl]-3-yl)methyl]amino}cyclohexyl]imino}methyl)[1,1'-biphenyl]-2-ol; cis-1,2-Diaminocyclohexane salalen ligand; cis-DACH salalen ligand; Bis(pentafluorophenyl) salalen ligand
Molecular Formula: C32H22F10N2O2
Molecular Weight: 656.51
Linear Structural Formula: C32H22F10N2O2
Purity: 98%
Application: Developed by Albrecht Berkessel's lab, this is the first catalyst system that allows catalytic enantioselective epoxidation of non-conjugated terminal double bonds with hydrogen peroxide as the oxidant. Eradicating multiple steps and kinetic resolution, this chiral ligand, when used with Ti(OiPr)4 provides a one-step route to enantiopure epoxides that are important intermediates for synthesis of bioactive compounds. Catalyst is recyclable under some conditions. For best results, pentafluorobenzoic acid (P5360) or tetra-n-butylammonium hydrogensulfate (155837) is recommended as a co-catalyst.
Other Notes: Titanium cis-1,2-Diaminocyclohexane Salalen Catalysts of Outstanding Activity and Enantioselectivity for the Asymmetric Epoxidation of Nonconjugated Terminal Olefins with Hydrogen Peroxide