Synonyms: 4-{4-(1-Methyl-1H-pyrazol-4-yl)-1-[2-(1-methyl-1H-pyrazol-4-yl)-ethyl]-1H-imidazol-5-yl}-benzonitrile
Molecular Formula: C20H19N7
Molecular Weight: 357.41
Linear Structural Formula: C20H19N7
MDL Number: MFCD28166490
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: BAZ2-ICR is a chemical probe for BAZ2A/B bromodomains with >100-fold selectivity over other bromodomains, with the exception of CECR2 (15-fold selectivity). BAZ2A is an essential component of the nucleolar remodeling complex (NoRC), which mediates recruitment of histone modifyine enzymes and DNA methylase involved in the silencing of ribosomal RNA transcription by RNA polymerase I. BAZ2B is believed to be involved in regulating nucleosome mobilization along linear DNA. BAZ2-ICR binds to BAZ2A with a KD of 109 nM (ITC) and to BAZ2B with a KD of 170 nM (ITC). BAZ2-ICR also shows accelerated Fluorescence recovery after photobleaching (FRAP) recovery at 1 muM in the BAZ2A FRAP assay. For full characterization details, please visit the BAZ2-ICR probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
Other Notes: BAZ2-ICR has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the BAZ2-ICR probe summary on the Chemical Probes Portal website.