Synonyms: N4-[1-[(4-Cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide
Molecular Formula: C24H16F4N6O2
Molecular Weight: 496.42
Linear Structural Formula: C24H16F4N6O2
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: BAY-876 is a potent, highly selective, cell-permeable inhibitor of glucose transporter GLUT1. It had an IC50 value of 2 nM in vitro and inhibited glucose uptake by Hela-MaTu cells with an IC50 value of 3.2 nM. BAY-876 was at least 130-fold selective for GLUT1 relative to GLUT2, GLUT3, GLUT4 and a panel of 18 kinases and 68 proteins. For full characterization details, please visit the BAY-876 probe summary on the Structural Genomics Consortium (SGC) website.BAY-588 is the negative control for the active probe, BAY-876. BAY-588 is available from Sigma. To learn more about and purchase BAY-588, click here.To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc