A VEGFR inhibitor (IC50s = 0.82, 0.037, and 0.42 µM for hVEGFR1, 2, and 3, respectively); also inhibits Tie2 and RET with IC50 values of 0.65 and 0.41, respectively; reduces inflammation in a mouse model of psoriasis and in pig models of contact hypersensitivity and UV-B-induced erythema.