Application
Bafilomycin A1 is a valuable tool for distinguishing between different types of ATPases and inhibitor of endosomal acidification. Furthermore, Bafilomycin A1 was found to block lysosomal cholesterol trafficking in macrophages.
Other Notes
Bafilomycin A1 solution is provided in concentration of 0.16 mM. Typical concentrations for use in cell culture are 50-100 nM.
Biochem/physiol Actions
Bafilomycin A1 is a macrolide antibiotic. Bafilomycin A1 acts as a potent and selective inhibitor of vacuolar-type H+-ATPase.