Synonyms: (S)-5-Chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine; 5-Chloro-N2-[(1S)-1-(5-fluoro-2-pyrimidinyl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine; AZD-1480
Molecular Formula: C14H14ClFN8
Molecular Weight: 348.77
Linear Structural Formula: C14H14ClFN8
Purity: >=98% (HPLC)
Storage: -20C
Application: AZD1480 has been used as an inhibitor of janus kinase 2 (JAK2) and signal transducer and activator of transcription 3 (STAT3) in an in vitro cell model of upper gastrointestinal adenocarcinoma. It has also been used in combination with bortezomib to study tumor-associated macrophage-mediated survival of myeloma cells.
Biochem Physiol Actions: AZD1480 is an orally active, potent and selective inhibitor of Janus kinases JAK1 and JAK 2 with selectivity for JAK2 as evidenced by IC50 values of 1.3 nM for JAK1 and<0.4 nm for jak2 in enzyme assays. azd1480 inhibits endogenous as well as il-6 induced stat3 activation. azd1480 reduces myeloid cell-mediated angiogenesis and metastasis. azd1489 is an effective anticancer agent in bot adult and pediatric human tumors. <>