Synonyms: 9-Cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-one; AZ-3146
Molecular Formula: C24H32N6O3
Molecular Weight: 452.55
Linear Structural Formula: C24H32N6O3
MDL Number: MFCD18384959
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: AZ3146 is a potent and specific inhibitor of monopolar spindle 1 kinase (Mps1; IC50 = 35 nM), an important regulator of Spindle Assembly Checkpoint (SAC). AZ3146 treated HeLa cells override SAC, and quickly enter mitosis, with a reduced mitosis completion time of 32 minutes. 50% of treated cells entered anaphase without complete chromosomal alignment.