Synonyms: 1[[1[4(Dimethylamino)phenyl]cyclopentyl]methyl]3[2,6di(propan2yl)phenyl]urea hydrochloride; ATR 101; ATR101; CI-984; N-[2,6-bis(1-Methylethyl)phenyl]-N-[[1-[4-(dimethylamino)phenyl]cyclopentyl]methyl]urea hydrochloride; Nevanimibe HCl; PD 132301 HCl; PD 132301-02; PD 132301-2; PD132301 HCl; PD132301-02; PD132301-2
Molecular Formula: C27H39N3O·HCl
Molecular Weight: 458.08
Linear Structural Formula: C27H39N3O·HCl
MDL Number: MFCD00899568
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: ATR-101 (PD 132301-02; Nevanimibe HCl) is an orally active, potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT1, SOAT1) inhibtior (IC50 = 52 nM; intestinal microsome from cholesterol-fed rabbits) that reduces plasma cholesterol in both acute (by 77%; 50 mg/kg po.) and chronic (by 80%; 10 mg/kg po.) cholesterol-fed rat models. In addition, ATR-101 is reported to exhibit therapeutic efficacy against adrenocortical carcinoma (ACC), congenital adrenal hyperplasia (CAH), and Cushing's syndrome (CS).