Synonyms: 4-[4-(1H-Imidazol-1-yl)phenyl]-N-2-propyn-1-yl-2-pyrimidinamine
Molecular Formula: C16H13N5
Molecular Weight: 275.31
Linear Structural Formula: C16H13N5
Purity: >=98% (HPLC)
Storage: 2-8C
Biochem Physiol Actions: AP-C5 is a potent and selective inhibitor of the guanosine 3',5'-cyclicmonophosphate (cGMP)-dependent protein kinase II (cGKII)that selectively blocks cGKII dependent phosphorylation of the vasodilator-stimulated phosphoprotein (VASP) in intestinal organoids. AP-C5 mitigates secretory response provoked by the GCC-activating Escherichia coli heat-stable toxin (STa) in mouse small intestinal tissue.