Synonyms: [(S)-1-Carboxy-2-phenylethyl]carbamoyl-L-arginyl-L-valyl-argininal
CAS Number: 37691-11-5
Formula: C27H44N10O6
Formula Weight: 604.7
Linear Formula: C27H44N10O6
MDL No.: MFCD00135959
Storage: -20C
Beilstein Registry Number: 6837629
EC Number: 253-631-0
UNSPSC Code: 12352202
General description: Chemical structure: peptide
Biochem/physiol Actions: Inhibits serine/cysteine proteases and some trypsin-like proteases. Compare activity to that of leupeptin. Used to evaluate the role of proteases in cell transformations. Used to help identify new proteases.
Biochem/physiol Actions: Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.
Unit Definition: 1 U corresponds to the amount of inhibitor which reduces the trypsin activity by 1 BAEE-U. (1 BAEE-U is the amount of enzyme which increases the absorbance at 253 nm by 0.001 per minute at pH 7.6 and 25C; BAEE, Cat. No. 12880, as substrate)
Other Notes: Protease inhibitor
RTECS: YV9350700
RIDADR: NONH for all modes of transport
WGK Germany: 3
Symbol: GHS07
Signal Word: Warning
Hazard Statements: H302