The gene ZSWIM6 (zinc finger SWIM domain-containing protein 6) is mapped to human chromosome 5q12. The protein has a SWIM zinc-finger-like domain which might be involved in DNA binding or protein-protein interaction.
Synonyms: Anti-KIAA1577; Anti-Zinc finger, SWIM-type containing 6
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: ZSWIM6 (zinc finger SWIM domain-containing protein 6) is linked with neurodevelopmental disorders. Absence of it in mice causes decrease in striatal volume and alterations in medium spiny neuron shape. These changes result in abnormal motor control, such as hyperactivity, defects in rotarod performance and repetitive movements. Mutations in the ZSWIM6 gene are associated with acromelic frontonasal dysostosis (AFND).
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