Zinc finger 703 (ZNF703), also referred to as zinc finger elbow-related proline domain protein 2 (zeppo2) and nocA-like zinc finger 1 (NoLZ1), belongs to the nocA-elbow (elB)-tlp (NET) protein family. ZNF703 is ubiquitously expressed in human tissue and it is predominantly expressed in lateral ganglionic eminence (LGE). The protein is encoded by the gene mapped to human chromosome 10.The encoded protein is characterized with typical C2H2 zinc-finger motif.
Synonyms: Anti-FLJ45745; Anti-MGC2555; Anti-zinc finger protein 503
Storage: -20C
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Biochem Physiol Actions: Zinc finger 703/ nocA-like zinc finger 1 (NoLZ1) control development and function of striatal neurons by promoting retinoic acid signaling in lateral ganglionic eminence (LGE). The protein might function as a transcriptional repressor. NOLZ1 expression in vLGE (ventral LGE) can be regulated by Gro-TLE co- repressor. ZNF703 plays a crucial role in mammary gland homeostasis and alteration in the expression of this protein might increase the risk for breast cancer development.
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