Zinc finger protein 408 (ZNF408) is a transcription factor consisting of 720 amino acids. It belongs to the C2H2 zinc finger proteins family. The gene encoding this protein is located on chromosome 11 and consists of five exons.
Synonyms: Anti-PR domain zinc finger protein 17; Anti-Zinc finger protein 408
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Zinc finger protein 408 (ZNF408) binds with a high affinity to DNA. It is suggested to have a role in protein-protein interactions for chromatin-mediated gene expression. Mutations in the gene encoding ZNF408 are associated with abnormal retinal vasculogenesis.
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