Synonyms: Anti-KOX18; Anti-PHZ-37; Anti-ZNF139; Anti-ZNF36; Anti-ZSCAN33
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: ZKSCAN1 (Zinc finger with KRAB and SCAN domains 1) is a transcription factor belonging to the zinc finger Krüppel family. It contains Cys2-His2 (C2H2) zinc finger domain. It plays an important role in the DNA repair mechanism. It is associated with several developmental and malignant disorders, specifically with the split hand and foot disease (SHFD1). It is overexpressed in the gastric cancer cells and more prominent in the metastasis process. In gastric cancer cells, it restricts cell invasion and migration.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC