Synonyms: Anti-KIAA0569; Anti-SIP-1; Anti-ZFHX1B; Anti-zinc finger E-box binding homeobox 2
Storage: -20C
Application: Anti-ZEB2 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Zinc finger E-box-binding homeobox 2 is a protein encoded by the ZEB2 gene in humans. It is a transcriptional repressor of E-cadherin, leading to epithelial-mesenchymal transition (EMT). It directly induces cadherin-11 transcription in Sp1-dependent manner. The gene up-regulates Sp1 by enhancing Sp1 protein stability. Sp1 is critical for ZEB2-induced cancer cell invasion, mainly through induction of cadherin-11 and integrin a5. The gene may have significant role in tumor progression and metastasis. The gene may be associated with renal cell carcinoma (RCC).
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC