Synonyms: Anti-HIP14; Anti-HIP3; Anti-HSPC294; Anti-HYPH; Anti-KIAA0946; Anti-Zinc finger, DHHC-type containing 17
Storage: -20C
Application: Anti-ZDHHC17 (AB1) antibody produced in rabbit is suitable for western blotting at a concentration of 1mug/mL.
Biochem Physiol Actions: ZDHHC17 is a palmitoyl acyl transferase (PAT) expressed primarily in insulin-positive cells in islets of Langerhans. Overexpression of HIP14 is related to a reduction in IL-1beta-induced NF-kappaB activity and it can also protect against IL-1beta-mediated apoptosis. Additionally, it is a ClipR-59 palmitoyltransferase that modifies the ClipR-59 plasma membrane binding and hence regulates the Akt signaling as well as Glut4 membrane translocation in adipocytes. It also facilitates the Mg2+ transport.