Palmitoyltransferase ZDHHC13 (UniProt: Q8IUH4; also known as EC: 2.3.1.22, Huntingtin-interacting protein 14-related protein, HIP14-related protein, Huntingtin-interacting protein HIP3RP, Putative MAPK-activating protein PM03, Putative NF-kappa-B-activating protein 209, Zinc finger DHHC domain-containing protein 13, DHHC-13) is encoded by the ZDHHC13 (also known as HIP14L, HIP3RP) gene (Gene ID: 54503) in human. DHHC-13 is a multi-pass membrane protein that serves as a palmitoyl acyltransferase (PAT) specific for a subset of neuronal proteins, including HD and GAD2 and may play a role in the pathogenesis of Huntington disease (HD). It is reported to be dysfunctional in the presence of the HD mutation and HIP-14 deficient mice are shown to develop features of HD. DHHC-13 also plays a role in cellular magnesium homeostasis. It contains a DHHC domain (aa 426-476 in isoform 1 and 250-300 in isoform 2), which is required for its palmitoyltransferase activity. (Ref.: Young, FB et al. (2011). Prog. Neurobiol. 97(2); 220-238).
Synonyms: Palmitoyltransferase ZDHHC13, EC: 2.3.1.22, Huntingtin-interacting protein 14-related protein, HIP14-related protein, Huntingtin-interacting protein HIP3RP, Putative MAPK-activating protein PM03, Putative NF-kappa-B-activating protein 209, Zinc finger DH
Application: Research CategoryNeuroscience
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