Zinc finger CCHC-type containing 8 (ZCCHC8) is a nuclear protein, encoded by the gene mapped to human chromosome 12q24.31. The encoded protein contains a zinc-knuckle domain and a proline-rich region.
Synonyms: Anti-DKFZp434E2220; Anti-Zinc finger, CCHC domain containing 8
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Zinc finger CCHC-type containing 8 (ZCCHC8) acts as a substrate for glycogen synthase kinase-3 (GSK3) and plays a vital role in RNA metabolism. ZCCHC8 expression is elevated in neuroblastoma patients. ZCCHC8 along with hMTR4 (an ATP-dependent RNA helicase) and the RNA-binding motif protein-7 (RBM7) forms a trimeric human nuclear exosome targeting (NEXT) complex, which stimulates exosomal degradation of non-coding RNAs.
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