YEATS4 is an oncogene that negatively regulates the p21-p53 pathway. Amplification of YEATS4 has been linked to the pathogenesis of non-small cell lung cancers (NSCLC).Rabbit Anti-YEATS4 antibody recognizes chicken, bovine, zebrafish, canine, human, mouse, and rat YEATS4.
Synonyms: Anti-YEATS domain containing 4
Storage: -20C
Application: Rabbit Anti-YEATS4 antibody can be used for western blot (0.5mug/ml) and immunohistochemistry (4-8mug/ml, using paraffin-embedded tissues) assays.
Biochem Physiol Actions: YEATS4 is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors.