Synonyms: Anti-Lysine deficient 1; Anti-PRKWNK1; Anti-Protein kinase
Storage: -20C
UNSPSC Code: 12352203
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General description: WNK1 (WNK lysine deficient protein kinase 1) gene is mapped to human chromosome 12p13.33. The gene is ubiquitously expressed. The encoded protein contain an active PY motif of short linear proline sequence.
General description: The WNK1 gene encodes a cytoplasmic serine-threonine kinase expressed in distal nephron.[supplied by OMIM]
Biochem/physiol Actions: WNK is known to influence the activity of chloride transporters such as members of the SLC12 family. WNK1 regulates ion transportation in kidney and maintains chloride concentration in the neurons. It maintains cell volume during the change in the solute concentration. Osmotic stress and chloride depletion within the cell upregulates WNK1 (WNK lysine deficient protein kinase 1) expression. Mutations in WNK1 leads to familial hyperkalemic hypertension, a Mendelian disorder characterized with thiazide-sensitive hypertension, hyperkalemia, and normal glomerular filtration rate. It is associated with hereditary syndromes like renal disease pseudohypoaldosteronism type II (PHAII) and the neurological disease hereditary sensory neuropathy 2.
Immunogen: WNK1 (Q9H4A3, 2266-2302)This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human WNK1.
Physical form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
RIDADR: NONH for all modes of transport
WGK Germany: nwg