WIPF2 (WAS/WASL interacting protein family, member 2)/WICH (WIP- and CR16-homologous protein)/ WIRE (another N-WASP-binding member of the family) is a member of the Wiskott-Aldrich syndrome proteins (WASP) family. It has a verprolin homology domain. This gene located on human chromosome 17q21.
Synonyms: Anti-WAS/WASL-interacting protein family member 2; Anti-WASP-interacting protein-related protein; Anti-WIP- and CR16-homologous protein; Anti-WIP-related protein
Storage: -20C
Application: Anti-WIPF2 antibody has been used in immunofluorescence and immunoblot analysis.
Biochem Physiol Actions: WIPF2 (WAS/WASL interacting protein family, member 2)/WICH (WIP- and CR16-homologous protein)/ WIRE (another N-WASP-binding member of the family) participates in actin-microspike formation. It modulates the generation of invadopodium and maturation in human breast cancer cell invasion. This protein plays an important role in matrix degradation and cell migration in diverse matrices. WIPF2 is also involved in the assembly of the actin cytoskeleton, mediated by WASP.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC