Wiskott-Aldrich Syndrome protein (WAS) is a hematopoietic-specific protein. It is expressed in lymphocytes, spleen, and thymus. WAS mainly is involved in the stimulation of the actin nucleation factor, Arp2/3, complex for actin polymerization and actin cytoskeleton architecture stabilization in hematopoietic cells. It possess a C-terminal tripartite VCA (verprolin,central, acidic) domain.
Synonyms: Anti-WASp antibody produced in rabbit; Anti-Wiskott-Aldrich syndrome protein antibody produced in rabbit
Storage: -20C
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Biochem Physiol Actions: In WAS (Wiskott-Aldrich Syndrome), protein the VCA (verprolin,central, acidic) domain binds to the Arp (actin-related protein)-2/3 complex via the V region to activate the complex as well as to stimulate actin polymerization. WAS has also a CRIB (Cdc42- and Rac-interactive binding) domain for binding to active GTP-bound form of Cdc42 (cell division cycle 42). The WAS activity is regulated by formation an auto-inhibited loop structure. It also plays a vital role in cytoplasmic tyrosine kinase pathway in B-lineage cells.
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