VMP1 (vacuole membrane protein 1) gene is mapped to human chromosome 17q23.1. VMP1 is a conserved multi-spanning transmembrane protein. The protein contains many endoplasmic reticulum micro-domains and six hydrophobic regions. It localizes to the intracellular membranes of the endoplasmic reticulum and the Golgi apparatus.
Synonyms: Anti-EPG3; Anti-TANGO5; Anti-TMEM49
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: VMP1 (vacuole membrane protein 1) is associated with the process of tumor metastasis and is strongly involved in balancing apoptosis and autophagy. Depletion of VMP1 (vacuole membrane protein 1) in HeLa (immortal cell line) cells might inhibit autophagy. VMP1 might serve as a therapeutic target in human ovarian cancer, as its regulation is associated with the apoptosis and metastasis of ovarian cancer. Downregulation of VMP1 might reduce cancer cell growth and metastasis. VMP1 is considered as stress-inducible gene in organs affected by acute inflammatory responses. VMP1 is also known to support tight junction formation and cell-cell contacts by its interaction with Zonula Occludens-1 protein. The protein thus plays a role in maintaining the integrity and function of many membranous organelles in an evolutionarily conserved manner.
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