Vimentin is a specific type III intermediate filament (IF) protein. It is abundantly expressed in mesenchymal cells. The gene encoding vimentin is located on human chromosome 10p13.
Synonyms: Anti-VIM
Storage: -20C
Application: Anti-Vimentin antibody, Mouse monoclonal may be used in:
•immunoblotting
•immunofluorescence
•flow cytometry
•immunoprecipitation
•immunohistochemistry
Biochem Physiol Actions: Vimentin protein plays a significant role in supporting and anchoring the cellular position of organelles such as the nucleus, endoplasmic reticulum, mitochondria, maintenance of cell shape, the endurance of mechanical stress of mesenchymal cells and motility. Overexpression of the vimentin gene is observed in various epithelial cancers, including prostate, gastrointestinal tumors, central nervous system (CNS) tumors, breast, malignant melanoma and lung cancer.