Versican (VCAN) encodes a large chondroitin sulfate proteoglycan named as versican. It is expressed in human fibroblasts. It consists of a hyaluronic acid-binding domain at the amino-terminal end. In the C termini, two epidermal growth factor (EGF) like repeats, a lectin-like sequence, and a complement regulatory protein-like domain are present. At the center, there is a glycosaminoglycan attachment site.
Synonyms: Anti-CSPG2 antibody produced in rabbit; Anti-Chondroitin sulfate proteoglycan core protein 2; Anti-GHAP; Anti-Glial hyaluronate-binding protein; Anti-Large fibroblast proteoglycan; Anti-PG-M; Anti-Versican core protein precursor; AntiVCAN
Storage: -20C
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Biochem Physiol Actions: Versican (VCAN) is involved in cell recognition. It connects extracellular matrix components and cell surface glycoproteins. It binds hyaluronan to connect proteins. As a result, it forms the large aggregate for maintaining structural integrity. Mutation in VCAN is responsible for Wagner syndrome (WS), an autosomal dominant disorder. It affects various ocular features.
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