Vasorin (VASN) is a type I transmembrane protein, which contains a leucine-rich repeat motif, an epidermal growth factor-like motif, and a fibronectin type III-like motif in its extracellular region. It is majorly expressed in vascular smooth muscle cells, and its expression levels depend upon the developmental stage. This gene is present on human chromosome 16, and codes for a protein composed of 673 amino acid residues.
Synonyms: Anti-Protein slit-like 2; Anti-Vasorin precursor
Storage: -20C
Application: All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry. The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: Vasorin (VASN) binds to transforming growth factor (TGF)-ß, and suppresses TGFß signaling. It regulates the response to vascular injury, and is under-expressed during vessel repair in arterial injury. The suppressed expression of VASN during repair is responsible for neointimal formation. It might therefore act as a therapeutic target for vascular fibro-proliferative disorders. ADAM17 (A disintegrin and a metalloprotease domain) regulates the activity of vasorin and thus, indirectly controls TGFß. It also regulates TGFß-driven epithelial-to-mesenchymal transition.
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