USP30 is encoded by the gene mapped to human chromosome 12q24.11. The encoded protein belongs to the ubiquitin-specific protease family.
Synonyms: Anti-Deubiquitinating enzyme 30; Anti-Ubiquitin carboxyl-terminal hydrolase 30; Anti-Ubiquitin thioesterase 30; Anti-Ubiquitin-specific-processing protease 30
Storage: -20C
Application: Anti-USP30 antibody produced in rabbit has been used in western blotting.
Biochem Physiol Actions: USP30 (ubiquitin specific peptidase 30) is involved in the maintenance of mitochondrial morphology through the deubiquitination. It has been reported that USP30 plays an important role in the Parkinson's disease. Overexpressed USP30 generates damaged mitochondria and blocks parkin's ability to mediate mitophagy by removing parkin attached ubiquitin. On the other end, reduced activity of USP30 causes enhanced mitochondrial degradation in neurons. Research data has concluded that inhibited expression of USP30 plays a positive role in the Parkinson's disease by promoting mitochondrial clearance and quality control.
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