Synonyms: Anti-Deubiquitinating enzyme 13 antibody produced in rabbit; Anti-ISOT-3 antibody produced in rabbit; Anti-Isopeptidase T-3 antibody produced in rabbit; Anti-Ubiquitin carboxyl-terminal hydrolase 13 antibody produced in rabbit; Anti-Ubiquitin thioesterase 13 antibody produced in rabbit; Anti-Ubiquitin-specific-processing protease 13 antibody produced in rabbit
Storage: -20C
Application: Anti-USP13 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem Physiol Actions: USP13 (Ubiquitin specific peptidase 13) is a deubiquitinating enzyme involved in the deubiquitination of microphthalmia-associated transcription factor (MITF). It is highly expressed in ovary, testes and lesser extent in other tissues. MITF is a key component of melanocyte development. USP13 generates stable and upregulated MITF protein through the deubiquitination pathway. Therefore, suppression of USP13 can cause dramatic loss of MITF protein. Studies have suggested that USP13 may have therapeutic aspects in melanoma cells. It has been reported that USP13 may play an important role in the JAK-STAT signaling pathway. It regulates type I and type II interferon signaling by deubiquitinating and stabilizing STAT1.
Legal Information: Prestige Antibodies is a registered trademark of Sigma-Aldrich Co. LLC